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Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases

Wayne State University researchers have demonstrated that inhibition of pro-survival kinase, AKT, using the transgene, Trb3, expressed in oligodendrocytes, leads to less brain white matter than controls. Moreover, Trb3 introduction into an animal model of the human disease, Pelizaeus Merzbacher disease (PMD) leads to less myelin thickness and fewer...

Published: 3/31/2014 | Inventor(s): Alexander Gow, Cherie Southwood

Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's

Category(s): Biotechnology, Life Science, Neurological disorders, Oncology, Therapeutics