Search Results - therapeutics

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The invention comprises a composition and methods for inhibiting cytochrome P450 enzyme activity and, in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. It is believed that 6',7'-dihydroxybergamottin, a furanocoumarin, is the compound primarily responsible for the inhibitory effects of grapefruit...

Published: 2/6/2014 | Inventor(s): Patrick Woster, David Edwards

Keywords(s):

Category(s): Therapeutics, Life Science, Oncology

New Immunotherapies for Cancer

Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tumors....

Published: 3/31/2014 | Inventor(s): Zhongwu Guo, Qianli Wang, Shouchu Tang

Keywords(s): Cancer Therapies, Drug Delivery, Pharmaceuticals, Therapeutics, Vaccines

Category(s): Therapeutics, Life Science, Diseases, Oncology

Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases

Wayne State University researchers have demonstrated that inhibition of pro-survival kinase, AKT, using the transgene, Trb3, expressed in oligodendrocytes, leads to less brain white matter than controls. Moreover, Trb3 introduction into an animal model of the human disease, Pelizaeus Merzbacher disease (PMD) leads to less myelin thickness and fewer...

Published: 3/31/2014 | Inventor(s): Alexander Gow, Cherie Southwood

Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's

Category(s): Biotechnology, Life Science, Neurological disorders, Oncology, Therapeutics

Mannich Bases of Conjugated Styryl Ketones

Detailed Description Human infectious diseases caused by fungi have increased markedly during the past 10 years due mainly to advances in medical care that involve prolonged immune suppression increased use of cytotoxic drugs in cancer chemotherapy and the advent of AIDS. As a result organisms such as Candida albicans have become opportunistic...

Published: 3/31/2014 | Inventor(s): Jonathan Dimmock, Elias Manavathu

Keywords(s): Anti-infective, Therapeutics

Category(s): Therapeutics, Life Science, Infectious disease

Folate Receptor Targeted Therapeutics for Cancer

Collaborative researchers at WSU and Duquesne University have developed a series of novel folate analogs that show selective toxicity toward tumor cells expressing high levels of the surface protein folate receptor. Typically, normal cells express low levels of folate receptors or such receptors exhibit apical localization and are not exposed to...

Published: 2/6/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Biotechnology, Cancer, Cancer Therapies

Category(s): Therapeutics, Life Science, Oncology

Tumor Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT)

WSU and Duquesne University scientist have isolated a unique series of pyrrolopyrimidine antifolate analogs that show selective cytotoxicity toward solid tumors such as ovarian, prostate or breast cancer cells that express the low pH “proton-coupled folate transporter” (PCFT). The acidic pH optimum (pH 5.5-6.5) of PCFT makes it an ideal target...

Published: 3/31/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Analog or Analogue, Breast Cancer, Cancer Therapies, Drug Delivery, Ovarian Cancer, Prostate Cancer

Category(s): Therapeutics, Life Science, Small molecule, Oncology

Visual Prostheses Based Upon Fiber-Optic Uncaging of Neurotransmitter Substances

Detailed Description A fiber optic cable may also be used to deliver light. The drug delivery system selectively delivers drugs to various types of neurological cells. In operation a solution of photoactivatable neuro-active drug is delivered to a pre-selected area in vivo and photoactivated in the solution at the pre-selected area to stimulate neurological...

Published: 3/31/2014 | Inventor(s): Patrick Mcallister, Raymond Iezzi, Gregory Auner, Gary Abrams

Keywords(s): Drug Delivery, Neurological, Neuroscience

Category(s): Medical, Life Science, Neurological disorders, Therapeutics, Drug Delivery

Method to Produce Immunostimulatory Proteins and Tether Them to the Membrane of Enveloped Virus Vaccines

Detailed Description Wayne State University researchers have developed a method to produce immunostimulatory cytokine proteins and tether them to the membrane of enveloped virus vaccines produced in cell culture. In vivo results to date indicate that this technology improves vaccine efficacy. Cytokines as soluble proteins have proven to be effective...

Published: 2/6/2014 | Inventor(s): Roy Sundick, Paul Roberts, Yufang Yang

Keywords(s):

Category(s): Therapeutics

Designer Aminoglycosides

Wayne State University researchers have synthesized a series of novel aminoglycoside antibiotics that have shown enhanced antibacterial activity, low susceptibility to existing resistance mechanisms and low toxicity when compared to currently marketed aminoglycosides. Aminoglycoside antibiotics have been used against a wide variety of bacterial...

Published: 2/6/2014 | Inventor(s): Shahriar Mobashery, Lakshmi Kotra, Jalal Haddad

Keywords(s): Antibiotics

Category(s): Therapeutics, Life Science, Small molecule, Diseases, Infectious disease

Method For Treating and/or Imaging Breast Cancer Using Radioactive Iodine

This invention involves treating a breast cancer patient by the administration of a radioisotope of iodine in a dosage of between 5 and 50 milliCuries over the course of a day. The therapeutic composition is designed for mammary tissue uptake and includes an inorganic radioactive iodide salt (e.g., alkali metal, alkali earth or transition metal...

Published: 3/31/2014 | Inventor(s): James Rillema

Keywords(s): Anti-cancer, Breast Cancer, Cancer Therapies, Imaging, Therapeutics

Category(s): Therapeutics, Life Science, Oncology, Receptors/targets, Diagnostic, Imaging

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