Search Results - therapeutics

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67DHB Grapefruit Inhibitor
The invention comprises a composition and methods for inhibiting cytochrome P450 enzyme activity and, in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. It is believed that 6',7'-dihydroxybergamottin, a furanocoumarin, is the compound primarily responsible for the inhibitory effects of grapefruit...
Published: 2/6/2014   |   Inventor(s): Patrick Woster, David Edwards
Keywords(s):  
Category(s): Therapeutics, Life Science, Oncology
New Immunotherapies for Cancer
Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tumors....
Published: 3/31/2014   |   Inventor(s): Zhongwu Guo, Qianli Wang, Shouchu Tang
Keywords(s): Cancer Therapies, Drug Delivery, Pharmaceuticals, Therapeutics, Vaccines
Category(s): Therapeutics, Life Science, Diseases, Oncology
Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases
Wayne State University researchers have demonstrated that inhibition of pro-survival kinase, AKT, using the transgene, Trb3, expressed in oligodendrocytes, leads to less brain white matter than controls. Moreover, Trb3 introduction into an animal model of the human disease, Pelizaeus Merzbacher disease (PMD) leads to less myelin thickness and fewer...
Published: 3/31/2014   |   Inventor(s): Alexander Gow, Cherie Southwood
Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's
Category(s): Biotechnology, Life Science, Neurological disorders, Oncology, Therapeutics
Mannich Bases of Conjugated Styryl Ketones
Detailed Description Human infectious diseases caused by fungi have increased markedly during the past 10 years due mainly to advances in medical care that involve prolonged immune suppression increased use of cytotoxic drugs in cancer chemotherapy and the advent of AIDS. As a result organisms such as Candida albicans have become opportunistic...
Published: 3/31/2014   |   Inventor(s): Jonathan Dimmock, Elias Manavathu
Keywords(s): Anti-infective, Therapeutics
Category(s): Therapeutics, Life Science, Infectious disease
Folate Receptor Targeted Therapeutics for Cancer
Collaborative researchers at WSU and Duquesne University have developed a series of novel folate analogs that show selective toxicity toward tumor cells expressing high levels of the surface protein folate receptor. Typically, normal cells express low levels of folate receptors or such receptors exhibit apical localization and are not exposed to...
Published: 2/6/2014   |   Inventor(s): Larry Matherly, Aleem Gangjee
Keywords(s): Biotechnology, Cancer, Cancer Therapies
Category(s): Therapeutics, Life Science, Oncology
Tumor Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT)
WSU and Duquesne University scientist have isolated a unique series of pyrrolopyrimidine antifolate analogs that show selective cytotoxicity toward solid tumors such as ovarian, prostate or breast cancer cells that express the low pH “proton-coupled folate transporter” (PCFT). The acidic pH optimum (pH 5.5-6.5) of PCFT makes it an ideal target...
Published: 3/31/2014   |   Inventor(s): Larry Matherly, Aleem Gangjee
Keywords(s): Analog or Analogue, Breast Cancer, Cancer Therapies, Drug Delivery, Ovarian Cancer, Prostate Cancer
Category(s): Therapeutics, Life Science, Small molecule, Oncology
Visual Prostheses Based Upon Fiber-Optic Uncaging of Neurotransmitter Substances
Detailed Description A fiber optic cable may also be used to deliver light. The drug delivery system selectively delivers drugs to various types of neurological cells. In operation a solution of photoactivatable neuro-active drug is delivered to a pre-selected area in vivo and photoactivated in the solution at the pre-selected area to stimulate neurological...
Published: 3/31/2014   |   Inventor(s): Patrick Mcallister, Raymond Iezzi, Gregory Auner, Gary Abrams
Keywords(s): Drug Delivery, Neurological, Neuroscience
Category(s): Medical, Life Science, Neurological disorders, Therapeutics, Drug Delivery
Method to Produce Immunostimulatory Proteins and Tether Them to the Membrane of Enveloped Virus Vaccines
Detailed Description Wayne State University researchers have developed a method to produce immunostimulatory cytokine proteins and tether them to the membrane of enveloped virus vaccines produced in cell culture. In vivo results to date indicate that this technology improves vaccine efficacy. Cytokines as soluble proteins have proven to be effective...
Published: 2/6/2014   |   Inventor(s): Roy Sundick, Paul Roberts, Yufang Yang
Keywords(s):  
Category(s): Therapeutics
Designer Aminoglycosides
Wayne State University researchers have synthesized a series of novel aminoglycoside antibiotics that have shown enhanced antibacterial activity, low susceptibility to existing resistance mechanisms and low toxicity when compared to currently marketed aminoglycosides. Aminoglycoside antibiotics have been used against a wide variety of bacterial...
Published: 2/6/2014   |   Inventor(s): Shahriar Mobashery, Lakshmi Kotra, Jalal Haddad
Keywords(s): Antibiotics
Category(s): Therapeutics, Life Science, Small molecule, Diseases, Infectious disease
Method For Treating and/or Imaging Breast Cancer Using Radioactive Iodine
This invention involves treating a breast cancer patient by the administration of a radioisotope of iodine in a dosage of between 5 and 50 milliCuries over the course of a day. The therapeutic composition is designed for mammary tissue uptake and includes an inorganic radioactive iodide salt (e.g., alkali metal, alkali earth or transition metal...
Published: 3/31/2014   |   Inventor(s): James Rillema
Keywords(s): Anti-cancer, Breast Cancer, Cancer Therapies, Imaging, Therapeutics
Category(s): Therapeutics, Life Science, Oncology, Receptors/targets, Diagnostic, Imaging
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