A Flexible Biocompatible Graphene Sensor for Point-of-care Diagnosis

Case ID:

A Wayne State University researcher has developed a novel method applying graphene to sensitive, high-throughput, multiplexing, for label-free and low-cost electrical biosensing applications.   Graphene is a flat single layer of sp2 bonded carbon atoms that are packed in a honey comb lattice, and have shown to have exceptional electronic, mechanical, and chemical properties.  Different to label-based detection, the label-free detection measures the change in inherent properties caused by the molecular binding on the sensor surface, such as charge mass, stress, or dielectric constants.  By modifying graphene’s attractive properties, the technique utilizes the naturally occurring defects found on the edges of graphene particles to attract “particles of interest.”   The label-free technique not only eliminates laborious, time-consuming procedures for tagging fluorescent probes, but also enables the determination of reaction kinetics of biomolecular interactions in real-time. The technology enables the development of inexpensive, disposable medical patches for a wide variety of detection and diagnosis applications

Commercial Applications:

·         Real-time, label free molecular detection

                    -Screening for cancer biomarkers

·         Point-of-care diagnosis

        -Blood glucose testing

       - Exposure to environment

       - Chlorestroal screening


Technological Advantages:

·         Reduces the complexity

         Eliminates laborious, time-consuming procedures for tagging fluorescent probes


·         Mitigates response time

         Enables the determination of reaction kinetics of biomolecular interactions in real-time.


·         Higher Accuracy

         Graphene’s hydrophobic properties eliminates problems of biofouling.


·         Surface Functionalization

         Flexible graphene structure allows for application in a variety of point-of-care settings.


·         Significant cost reductions

         Manufacturing costs

         Eliminate laboratory expenses

         Reduces response time and labor in clinical and at-home patient care settings


·         Increased patient empowerment


Patent Status:

Patent Pending


Patent Information:
For Information, Contact:
Nicole Grynaviski
Commercialization Principal
Wayne State University
Mark MinG-Cheng Cheng