Search Results - Life+Science

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Modified Ectodomain of Human EGFR as a Potential Anticancer Agent
Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...
Published: 2/6/2014   |   Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu
Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics
Category(s): Life Science, Biologicals, Diseases, Oncology
Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors
This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...
Published: 2/6/2014   |   Inventor(s): Leon Carlock, Maria Cypher
Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics
Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines
Improved DW-MRI analysis methods for detecting motor functions
Summary:Diffusion weighted MRI (DW-MRI) is an important imaging tool in mapping associated white matter pathways in the brain. WSU has developed a new software program that analyzes DW-MRI images using improved models (ICA+BSM) and algorithmic methods (DWI tractography & Kalman filter analysis). The WSU software can automatically identify primary...
Published: 2/6/2014   |   Inventor(s): Justin Jeong, Eishi Asano, Diane Chugani, Harry Chugani
Keywords(s):  
Category(s): Life Science, Software, MRI
Loop-Mediated Isothermal Amplification (LAMP) Assay for Meningitis
Summary: A novel LAMP assay has been developed for detection of Neisseria meningitidis (Nm) in patient samples. Six sets of unique primers have been designed which dramatically improve sensitivity of Nm detection and enable discrimination of the six major Nm serogroups (A, B, C, W-135, X, and Y) with limits as low as 1 (one) genomic copy per reaction....
Published: 2/6/2014   |   Inventor(s): Mitsuko Seki, Dong Wook Kim, Paul Kilgore
Keywords(s): Diagnostic, Disease, Vaccines
Category(s): Diagnostic, Life Science, Infectious disease, Research tools, Assays
67DHB Grapefruit Inhibitor
The invention comprises a composition and methods for inhibiting cytochrome P450 enzyme activity and, in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. It is believed that 6',7'-dihydroxybergamottin, a furanocoumarin, is the compound primarily responsible for the inhibitory effects of grapefruit...
Published: 2/6/2014   |   Inventor(s): Patrick Woster, David Edwards
Keywords(s):  
Category(s): Therapeutics, Life Science, Oncology
New Immunotherapies for Cancer
Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tumors....
Published: 3/31/2014   |   Inventor(s): Zhongwu Guo, Qianli Wang, Shouchu Tang
Keywords(s): Cancer Therapies, Drug Delivery, Pharmaceuticals, Therapeutics, Vaccines
Category(s): Therapeutics, Life Science, Diseases, Oncology
Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases
Wayne State University researchers have demonstrated that inhibition of pro-survival kinase, AKT, using the transgene, Trb3, expressed in oligodendrocytes, leads to less brain white matter than controls. Moreover, Trb3 introduction into an animal model of the human disease, Pelizaeus Merzbacher disease (PMD) leads to less myelin thickness and fewer...
Published: 3/31/2014   |   Inventor(s): Alexander Gow, Cherie Southwood
Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's
Category(s): Biotechnology, Life Science, Neurological disorders, Oncology, Therapeutics
Hyperaccumulation of Arsenic in S. Cerevisiae
Detailed Description WSU faculty developed an innovative biological technology that has promise to cost-effectively remove arsenic from drinking water. The technology employs the use of a genetically engineered strain of yeast with the ability to hyper-accumulate arsenic without releasing the arsenic back into the environment. The yeast is being...
Published: 3/31/2014   |   Inventor(s): Barry Rosen, Mallika Ghosh
Keywords(s): Reagents
Category(s): Environment, Life Science, Reagents, Research tools
Mannich Bases of Conjugated Styryl Ketones
Detailed Description Human infectious diseases caused by fungi have increased markedly during the past 10 years due mainly to advances in medical care that involve prolonged immune suppression increased use of cytotoxic drugs in cancer chemotherapy and the advent of AIDS. As a result organisms such as Candida albicans have become opportunistic...
Published: 3/31/2014   |   Inventor(s): Jonathan Dimmock, Elias Manavathu
Keywords(s): Anti-infective, Therapeutics
Category(s): Therapeutics, Life Science, Infectious disease
Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging
Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...
Published: 2/6/2014   |   Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf
Keywords(s): Biotechnology, Imaging
Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools
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