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Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...

Published: 2/6/2014 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...

Published: 2/6/2014 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines

Improved DW-MRI analysis methods for detecting motor functions

Summary:Diffusion weighted MRI (DW-MRI) is an important imaging tool in mapping associated white matter pathways in the brain. WSU has developed a new software program that analyzes DW-MRI images using improved models (ICA+BSM) and algorithmic methods (DWI tractography & Kalman filter analysis). The WSU software can automatically identify primary...

Published: 2/6/2014 | Inventor(s): Justin Jeong, Eishi Asano, Diane Chugani, Harry Chugani

Keywords(s):

Category(s): Life Science, Software, MRI

Loop-Mediated Isothermal Amplification (LAMP) Assay for Meningitis

Summary: A novel LAMP assay has been developed for detection of Neisseria meningitidis (Nm) in patient samples. Six sets of unique primers have been designed which dramatically improve sensitivity of Nm detection and enable discrimination of the six major Nm serogroups (A, B, C, W-135, X, and Y) with limits as low as 1 (one) genomic copy per reaction....

Published: 2/6/2014 | Inventor(s): Mitsuko Seki, Dong Wook Kim, Paul Kilgore

Keywords(s): Diagnostic, Disease, Vaccines

Category(s): Diagnostic, Life Science, Infectious disease, Research tools, Assays

67DHB Grapefruit Inhibitor

The invention comprises a composition and methods for inhibiting cytochrome P450 enzyme activity and, in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. It is believed that 6',7'-dihydroxybergamottin, a furanocoumarin, is the compound primarily responsible for the inhibitory effects of grapefruit...

Published: 2/6/2014 | Inventor(s): Patrick Woster, David Edwards

Keywords(s):

Category(s): Therapeutics, Life Science, Oncology

New Immunotherapies for Cancer

Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tumors....

Published: 3/31/2014 | Inventor(s): Zhongwu Guo, Qianli Wang, Shouchu Tang

Keywords(s): Cancer Therapies, Drug Delivery, Pharmaceuticals, Therapeutics, Vaccines

Category(s): Therapeutics, Life Science, Diseases, Oncology

Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases

Wayne State University researchers have demonstrated that inhibition of pro-survival kinase, AKT, using the transgene, Trb3, expressed in oligodendrocytes, leads to less brain white matter than controls. Moreover, Trb3 introduction into an animal model of the human disease, Pelizaeus Merzbacher disease (PMD) leads to less myelin thickness and fewer...

Published: 3/31/2014 | Inventor(s): Alexander Gow, Cherie Southwood

Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's

Category(s): Biotechnology, Life Science, Neurological disorders, Oncology, Therapeutics

Hyperaccumulation of Arsenic in S. Cerevisiae

Detailed Description WSU faculty developed an innovative biological technology that has promise to cost-effectively remove arsenic from drinking water. The technology employs the use of a genetically engineered strain of yeast with the ability to hyper-accumulate arsenic without releasing the arsenic back into the environment. The yeast is being...

Published: 3/31/2014 | Inventor(s): Barry Rosen, Mallika Ghosh

Keywords(s): Reagents

Category(s): Environment, Life Science, Reagents, Research tools

Mannich Bases of Conjugated Styryl Ketones

Detailed Description Human infectious diseases caused by fungi have increased markedly during the past 10 years due mainly to advances in medical care that involve prolonged immune suppression increased use of cytotoxic drugs in cancer chemotherapy and the advent of AIDS. As a result organisms such as Candida albicans have become opportunistic...

Published: 3/31/2014 | Inventor(s): Jonathan Dimmock, Elias Manavathu

Keywords(s): Anti-infective, Therapeutics

Category(s): Therapeutics, Life Science, Infectious disease

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 2/6/2014 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

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