Search Results - Biotechnology

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New Technology of Production of Properly Folded Protein

This invention is a new protein transduction method for efficient delivery of exogenous proteins into mammalian cells. In contrast to known protein transduction methods, this new approach has the capability of targeting transduced proteins to different cellular compartments, as well as protecting the proteins from degradation by cellular proteases....

Published: 2/6/2014 | Inventor(s): Jianjun Wang, Qianqian Li

Keywords(s): Protein

Category(s): Biotechnology

High Efficient Reagent that Transfers Protein into the Living Mammalian Cells

Published: 3/31/2014 | Inventor(s): Qianqian Li, Jianjun Wang

Keywords(s): Protein

Category(s): Biotechnology

Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases

Wayne State University researchers have demonstrated that inhibition of pro-survival kinase, AKT, using the transgene, Trb3, expressed in oligodendrocytes, leads to less brain white matter than controls. Moreover, Trb3 introduction into an animal model of the human disease, Pelizaeus Merzbacher disease (PMD) leads to less myelin thickness and fewer...

Published: 3/31/2014 | Inventor(s): Alexander Gow, Cherie Southwood

Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's

Category(s): Biotechnology, Life Science, Neurological disorders, Oncology, Therapeutics

Microvascular Pericytes are Adult Pluripotential Stem Cells

Detailed Description The existence of multipotent stem cells within the adult brain has been debated for some time. While the identity of this cell has been unknown it is clear that stem cells reside in specialized tissue (subventricular zone and subgranular zone) and that local microenvironments regulate their differentiation and self-renewal....

Published: 2/6/2014 | Inventor(s): Paula DorE-Duffy, Xuegian Wang, Andre Katychev

Keywords(s):

Category(s): Biotechnology

New Technology of Studying Protein Structure/Folding Functions in Living Mammalian Cells

Published: 2/6/2014 | Inventor(s): Qianqian Li, Jianjun Wang

Keywords(s): Protein

Category(s): Biotechnology

Novel Mammalian Putative Phosphatidylinositol-4-Phosphate-5-Kinase

Researchers at Wayne State University have discovered a novel mammalian gene which may be involved in membrane trafficking, more specifically, insulin-induced translocation of the fat/muscle-specific glucose transporter GLUT4. This material is a potentially valuable research tool for investigation relating to the diagnosis or therapy of diabetes....

Published: 3/31/2014 | Inventor(s): Assia Shisheva

Keywords(s): DNA, Drug Target, Therapeutics

Category(s): Biotechnology, Diseases, Life Science, Metabolic disorders, Therapeutics

Regulators of Peritoneal Healing and Adhesion Development

WSU researchers have identified a novel approach to reduce postoperative adhesion development. This invention identifies new targets for regulation of healing and fibrosis, so as to decrease or increase the process depending on the clinical need. NF-kappa has shown to be differently expressed in fibroblasts from normal peritoneum and adhesions....

Published: 2/6/2014 | Inventor(s): Michael Diamond, Ghassan Saed

Keywords(s):

Category(s): Biotechnology