Search Results - diseases

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Modified Ectodomain of Human EGFR as a Potential Anticancer Agent
Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...
Published: 2/6/2014   |   Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu
Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics
Category(s): Life Science, Biologicals, Diseases, Oncology
New Immunotherapies for Cancer
Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tumors....
Published: 3/31/2014   |   Inventor(s): Zhongwu Guo, Qianli Wang, Shouchu Tang
Keywords(s): Cancer Therapies, Drug Delivery, Pharmaceuticals, Therapeutics, Vaccines
Category(s): Therapeutics, Life Science, Diseases, Oncology
Designer Aminoglycosides
Wayne State University researchers have synthesized a series of novel aminoglycoside antibiotics that have shown enhanced antibacterial activity, low susceptibility to existing resistance mechanisms and low toxicity when compared to currently marketed aminoglycosides. Aminoglycoside antibiotics have been used against a wide variety of bacterial...
Published: 2/6/2014   |   Inventor(s): Shahriar Mobashery, Lakshmi Kotra, Jalal Haddad
Keywords(s): Antibiotics
Category(s): Therapeutics, Life Science, Small molecule, Diseases, Infectious disease
Novel Dual and Triple Acting CNS Compounds with Potential as Antidepressants, Medications for Attention Deficit Disorders and other Related Neuro-disorders
Wayne State University researchers have identified compounds with a unique molecular template exhibiting reuptake inhibition activity for both at the norepinephrine and serotonin transporters in the CNS. In addition, some of these molecules also exhibit triple reuptake activity for the dopamine, serotonin and norepinephrine transporters. These...
Published: 2/6/2014   |   Inventor(s): Aloke Dutta
Keywords(s): Antidepressants, Attention Deficit Disorders, Neuro-disorders, Neuroscience
Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders
Novel Hybrid Series of Compound Derived from 2-Aminotetralin and Piperazine Based Derivatives: Characterization for D1, D2, D3, D4 and other Serotonin Receptor Subtypes Binding
A series of compounds derived from 2-aminotetralin and piperazine fragments have been synthesized, which exhibit high CNS activity in vivo and in vitro. Some of the selected lead compounds have exhibited potent in vivo activity in a Parkinson’s disease animal model with long extended duration of action. In particular, these compounds show high...
Published: 2/6/2014   |   Inventor(s): Aloke Dutta, XianG-Shu Fei
Keywords(s):  
Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders
Drug-Dendrimer Nanoparticles for Targeted Treatment of Neuroinflammation
Highly effective dendrimer-drug based compositions and methods for treatment have been developed that target neuroinflammation both in the brain and the retina upon intravenous administration. The nanodevices overcome the blood-brain barrier (BBB) and deliver drugs to target cells (activated microglia and astrocytes) producing dramatic therapeutic improvements....
Published: 3/31/2014   |   Inventor(s): Rangaramanujam Kannan, Raymond Iezzi, Bharath Rajaguru, Sujatha Kannan
Keywords(s): Alzheimer's Disease, Compound, Disease, Drug Delivery, Imaging, Nanomaterials, Nanotechnology, Neural Probes, Neuro-disorders, Parkinson's, Pharmaceuticals, Therapeutics
Category(s): Drug Delivery, Therapeutics, Diseases, Life Science, Nano-based, Vision, Imaging, Neurological disorders, Dendrimer
DNA Molecule Encoding the B3 Adrenegic Receptor
The B3-Adrenergic receptor protein and DNA which encodes same, vectors containing the DNA, host cells transformed with the vectors and methods of using the protein, the DNA and the transformed host cells. Widely licensed on a non-exclusive basis for diabetes research. U.S. Patent #5,364,772.
Published: 3/31/2014   |   Inventor(s): James Granneman, Kristine Lahners, Donald Rao
Keywords(s): Disease, DNA, Drug Target, Therapeutics
Category(s): Drug Screening, Diseases, Life Science, Small molecule, Therapeutics, Metabolic disorders
Novel Mammalian Putative Phosphatidylinositol-4-Phosphate-5-Kinase
Researchers at Wayne State University have discovered a novel mammalian gene which may be involved in membrane trafficking, more specifically, insulin-induced translocation of the fat/muscle-specific glucose transporter GLUT4. This material is a potentially valuable research tool for investigation relating to the diagnosis or therapy of diabetes....
Published: 3/31/2014   |   Inventor(s): Assia Shisheva
Keywords(s): DNA, Drug Target, Therapeutics
Category(s): Biotechnology, Diseases, Life Science, Metabolic disorders, Therapeutics
Inhibitors of Matrix Metalloproteinases
Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but not...
Published: 2/6/2014   |   Inventor(s): Shahriar Mobashery, Rafael Fridman
Keywords(s):  
Category(s): Therapeutics, Life Science, Small molecule, Diseases