Search Results - diseases

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Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...

Published: 2/6/2014 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

New Immunotherapies for Cancer

Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tumors....

Published: 3/31/2014 | Inventor(s): Zhongwu Guo, Qianli Wang, Shouchu Tang

Keywords(s): Cancer Therapies, Drug Delivery, Pharmaceuticals, Therapeutics, Vaccines

Category(s): Therapeutics, Life Science, Diseases, Oncology

Designer Aminoglycosides

Wayne State University researchers have synthesized a series of novel aminoglycoside antibiotics that have shown enhanced antibacterial activity, low susceptibility to existing resistance mechanisms and low toxicity when compared to currently marketed aminoglycosides. Aminoglycoside antibiotics have been used against a wide variety of bacterial...

Published: 2/6/2014 | Inventor(s): Shahriar Mobashery, Lakshmi Kotra, Jalal Haddad

Keywords(s): Antibiotics

Category(s): Therapeutics, Life Science, Small molecule, Diseases, Infectious disease

Novel Dual and Triple Acting CNS Compounds with Potential as Antidepressants, Medications for Attention Deficit Disorders and other Related Neuro-disorders

Wayne State University researchers have identified compounds with a unique molecular template exhibiting reuptake inhibition activity for both at the norepinephrine and serotonin transporters in the CNS. In addition, some of these molecules also exhibit triple reuptake activity for the dopamine, serotonin and norepinephrine transporters. These...

Published: 2/6/2014 | Inventor(s): Aloke Dutta

Keywords(s): Antidepressants, Attention Deficit Disorders, Neuro-disorders, Neuroscience

Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders

Novel Hybrid Series of Compound Derived from 2-Aminotetralin and Piperazine Based Derivatives: Characterization for D1, D2, D3, D4 and other Serotonin Receptor Subtypes Binding

A series of compounds derived from 2-aminotetralin and piperazine fragments have been synthesized, which exhibit high CNS activity in vivo and in vitro. Some of the selected lead compounds have exhibited potent in vivo activity in a Parkinson’s disease animal model with long extended duration of action. In particular, these compounds show high...

Published: 2/6/2014 | Inventor(s): Aloke Dutta, XianG-Shu Fei

Keywords(s):

Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders

Drug-Dendrimer Nanoparticles for Targeted Treatment of Neuroinflammation

Highly effective dendrimer-drug based compositions and methods for treatment have been developed that target neuroinflammation both in the brain and the retina upon intravenous administration. The nanodevices overcome the blood-brain barrier (BBB) and deliver drugs to target cells (activated microglia and astrocytes) producing dramatic therapeutic improvements....

Published: 3/31/2014 | Inventor(s): Rangaramanujam Kannan, Raymond Iezzi, Bharath Rajaguru, Sujatha Kannan

Keywords(s): Alzheimer's Disease, Compound, Disease, Drug Delivery, Imaging, Nanomaterials, Nanotechnology, Neural Probes, Neuro-disorders, Parkinson's, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Therapeutics, Diseases, Life Science, Nano-based, Vision, Imaging, Neurological disorders, Dendrimer

DNA Molecule Encoding the B3 Adrenegic Receptor

The B3-Adrenergic receptor protein and DNA which encodes same, vectors containing the DNA, host cells transformed with the vectors and methods of using the protein, the DNA and the transformed host cells. Widely licensed on a non-exclusive basis for diabetes research. U.S. Patent #5,364,772.

Published: 3/31/2014 | Inventor(s): James Granneman, Kristine Lahners, Donald Rao

Keywords(s): Disease, DNA, Drug Target, Therapeutics

Category(s): Drug Screening, Diseases, Life Science, Small molecule, Therapeutics, Metabolic disorders

Novel Mammalian Putative Phosphatidylinositol-4-Phosphate-5-Kinase

Researchers at Wayne State University have discovered a novel mammalian gene which may be involved in membrane trafficking, more specifically, insulin-induced translocation of the fat/muscle-specific glucose transporter GLUT4. This material is a potentially valuable research tool for investigation relating to the diagnosis or therapy of diabetes....

Published: 3/31/2014 | Inventor(s): Assia Shisheva

Keywords(s): DNA, Drug Target, Therapeutics

Category(s): Biotechnology, Diseases, Life Science, Metabolic disorders, Therapeutics

Inhibitors of Matrix Metalloproteinases

Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but not...

Published: 2/6/2014 | Inventor(s): Shahriar Mobashery, Rafael Fridman

Keywords(s):

Category(s): Therapeutics, Life Science, Small molecule, Diseases