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Ruthenium-based caging of nitrile-containing enzyme inhibitors

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...

Published: 2/6/2014 | Inventor(s): Jeremy Kodanko, Claudia Turro

Keywords(s): Cancer, Pharmaceuticals

Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other