Search Results - cancer

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Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...

Published: 2/6/2014 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...

Published: 2/6/2014 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines

Folate Receptor Targeted Therapeutics for Cancer

Collaborative researchers at WSU and Duquesne University have developed a series of novel folate analogs that show selective toxicity toward tumor cells expressing high levels of the surface protein folate receptor. Typically, normal cells express low levels of folate receptors or such receptors exhibit apical localization and are not exposed to...

Published: 2/6/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Biotechnology, Cancer, Cancer Therapies

Category(s): Therapeutics, Life Science, Oncology

Galectin-3 Single Nucleotide Polymorphism rs4644 Predicts Human Cancer Risk Associated with Racial Disparity

This invention is a new diagnostic tool which allows prediction of cancer risk based on a single nucleotide polymorphism of a gene whose protein is over-expressed in various cancers. The polymorphism results in a single amino acid change. DNA analysis demonstrated that 98% of cancer patients tested had the mutation while normal donors did not....

Published: 3/31/2014 | Inventor(s): Avraham Raz, Pratima NangiA-Maker, Vitaly Balan

Keywords(s): Biotechnology, Cancer, Cancer risk, Diagnostics

Category(s): Diagnostic, Life Science, Oncology

Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...

Published: 3/31/2014 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice

A Wayne State University researcher has developed new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Oncology, Research tools

Ruthenium-based caging of nitrile-containing enzyme inhibitors

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...

Published: 2/6/2014 | Inventor(s): Jeremy Kodanko, Claudia Turro

Keywords(s): Cancer, Pharmaceuticals

Category(s): Chemicals, Drug Delivery, Life Science, Physical Sciences, Other

Derivation of Molecular Targets of Cancer and Aging Using Cellular Immortalization-Specific Gene-Expression

Detailed Description WSU faculty developed an approach to identify gene-expression changes in spontaneously immortalized human cell lines as compared to non-immortal cells. This approach led to the identification of molecular targets required for the long lifespan spontaneously acquired by cancer cells. These targets may provide a potential means...

Published: 3/31/2014 | Inventor(s): Sorin Draghici, Olga Studitskaia, Michael Tainsky

Keywords(s): Cancer, Drug Target

Category(s): Diagnostic, Life Science, Oncology

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

This invention is a method for the identification of MMP enzyme activity in tissue. MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed, in part, because there is no reliable biomarker to determine MMP activity in tissue. This invention...

Published: 3/31/2014 | Inventor(s): Avraham Raz, Rafael Fridman, Pratima NangiA-Maker

Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method

Category(s): Diagnostic, Life Science, Oncology

Establishment of a New Renal Cell Carcinoma Cell Line and a New Experimental Renal Tumor Model

A tumor cell line from a primary papillary renal cell carcinoma (RCC) (nuclear grade III/IV). This cell line, known as KCI-18, when implanted in the kidney of nude mice provides a xenograft tumor model of RCC. The KCI-18 cell line is highly tumorigenic, with lung metastases forming from the primary tumor as in human renal cell carcinoma. File...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Oncology, Research tools