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Whole body model of a 10-year-old child for pediatric injury prediction

Technology A computational whole body 10-year-old (YO) FE (Finite Element) model which is anatomically accurate based on the clinical images. The model was composed ofhigh quality elements for accurate stress/strain predictions and possessed high biofidelity to accurately predict body responses under external mechanical loadings. Preliminary verification...

Published: 2/6/2014 | Inventor(s): Haojie Mao, KinG-Hay Yang

Keywords(s):

Category(s): Automotive & Transportation, Research tools

Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...

Published: 2/6/2014 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...

Published: 2/6/2014 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines

Improved DW-MRI analysis methods for detecting motor functions

Summary:Diffusion weighted MRI (DW-MRI) is an important imaging tool in mapping associated white matter pathways in the brain. WSU has developed a new software program that analyzes DW-MRI images using improved models (ICA+BSM) and algorithmic methods (DWI tractography & Kalman filter analysis). The WSU software can automatically identify primary...

Published: 2/6/2014 | Inventor(s): Justin Jeong, Eishi Asano, Diane Chugani, Harry Chugani

Keywords(s):

Category(s): Life Science, Software, MRI

Co-polymer Stabilizers for Pressured Metered Dose Inhalers (pMDIs)

A series of novel co polymer surfactants with the general structure LAmEOnLAm were developed along with a Colloidal Probe Microscopy (CPM) method to optimize the surfactant composition using adhesion forces to improve stabilization of drug dispersions. This expands the range of biomolecules and micronized drug particles that can be formulated with pMDIs....

Published: 2/6/2014 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Assay, Asthma, Compound, Device, Drug Delivery, Formulation, Instrumentation, Method, Pharmaceuticals, Process, Therapeutics

Category(s): Chemicals, Drug Delivery, Pharmaceuticals, Instrumentation, Materials

Loop-Mediated Isothermal Amplification (LAMP) Assay for Meningitis

Summary: A novel LAMP assay has been developed for detection of Neisseria meningitidis (Nm) in patient samples. Six sets of unique primers have been designed which dramatically improve sensitivity of Nm detection and enable discrimination of the six major Nm serogroups (A, B, C, W-135, X, and Y) with limits as low as 1 (one) genomic copy per reaction....

Published: 2/6/2014 | Inventor(s): Mitsuko Seki, Dong Wook Kim, Paul Kilgore

Keywords(s): Diagnostic, Disease, Vaccines

Category(s): Diagnostic, Life Science, Infectious disease, Research tools, Assays

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