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The invention comprises a composition and methods for inhibiting cytochrome P450 enzyme activity and, in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. It is believed that 6',7'-dihydroxybergamottin, a furanocoumarin, is the compound primarily responsible for the inhibitory effects of grapefruit...

Published: 2/6/2014 | Inventor(s): Patrick Woster, David Edwards

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Category(s): Therapeutics, Life Science, Oncology