67DHB Grapefruit Inhibitor

Case ID:
96-387

The invention comprises a composition and methods for inhibiting cytochrome P450 enzyme activity and, in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. It is believed that 6',7'-dihydroxybergamottin, a furanocoumarin, is the compound primarily responsible for the inhibitory effects of grapefruit juice on cytochrome P450 enzyme activity. The compound is potentially useful as an inhibitor of cytochrome P450 by incorporating 67DHB into the formulation of a drug for the purpose of improving the bioavailability of the drug. It may also be useful by itself as a chemopreventive agent to reduce cancer risk.

References:

Issued Patent: 6,160,006

1997 "Synthesis and biological evaluation of 6',7'-dihydroxybergamottin (6,7-DHB), a naturally occurring inhibitor of cytochrome P450 3A4"
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol 7 (20) pp2593-2598

Direct Link:

http://wayne.testtechnologypublisher.com/technology/6921

Category(s):

Therapeutics

Life Science

Oncology

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For Information, Contact:

Nicole Grynaviski

Commercialization Principal

Wayne State University

nicole.grynaviski@wayne.edu

Inventors:

Patrick Woster

David Edwards