Search Results - mary+pflum

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Summary: This invention provides a high-throughput, cost-effective, isoform-selective, human-based HDAC activity assay useful for understanding the activity of the 11 different HDAC isoforms present in humans. HDAC (Histone deacetylase) proteins are key regulators in gene expression and HDAC inhibitors represent an important new drug discovery target...

Published: 2/6/2014 | Inventor(s): Mary Pflum

Keywords(s): Assay

Category(s): Drug Discovery, Life Science, Assays

Biologically active ATP-Analogs for tagging phosphoproteins

A novel Photo Cross Linking Assay (PCLA) for targeting protein phosphorylation Protein phosphorylation catalyzed by kinases and phosphatases act at critical control points that regulates many cellular processes. This central role makes them an attractive target for identifying largely untapped and important biomarkers for disease diagnostics. Understanding...

Published: 3/31/2014 | Inventor(s): Mary Pflum

Keywords(s): Assay, Biomarker, Protein

Category(s): Chemicals, Life Science, Research tools, Assays, Reagents