Search Results - drug+discovery

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Summary: This invention provides a high-throughput, cost-effective, isoform-selective, human-based HDAC activity assay useful for understanding the activity of the 11 different HDAC isoforms present in humans. HDAC (Histone deacetylase) proteins are key regulators in gene expression and HDAC inhibitors represent an important new drug discovery target...

Published: 2/6/2014 | Inventor(s): Mary Pflum

Keywords(s): Assay

Category(s): Drug Discovery, Life Science, Assays

Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice

A Wayne State University researcher has developed new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Oncology, Research tools

Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

A Wayne State University researcher has derived new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Research tools, Oncology

An In Vitro Model System for Studying Development of Human Preneoplastic Breast Disease

Wayne State University researchers have developed a novel model/assay system that recapitulates in vitro the in vivo processes that lead to breast cancer development and progression from preneoplastic tissue. This model is the first that demonstrates in vitro the de novo development and neoplastic conversion of functional alveolar units. Advantages...

Published: 3/31/2014 | Inventor(s): Malathy Shekhar, Larry Tait

Keywords(s): Assay, Breast Cancer

Category(s): Drug Discovery, Assays, Life Science, Oncology, Research tools

Establishment of a New Renal Cell Carcinoma Cell Line and a New Experimental Renal Tumor Model

A tumor cell line from a primary papillary renal cell carcinoma (RCC) (nuclear grade III/IV). This cell line, known as KCI-18, when implanted in the kidney of nude mice provides a xenograft tumor model of RCC. The KCI-18 cell line is highly tumorigenic, with lung metastases forming from the primary tumor as in human renal cell carcinoma. File...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Oncology, Research tools