Search Results - assay

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Co-polymer Stabilizers for Pressured Metered Dose Inhalers (pMDIs)

A series of novel co polymer surfactants with the general structure LAmEOnLAm were developed along with a Colloidal Probe Microscopy (CPM) method to optimize the surfactant composition using adhesion forces to improve stabilization of drug dispersions. This expands the range of biomolecules and micronized drug particles that can be formulated with pMDIs....

Published: 2/6/2014 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Assay, Asthma, Compound, Device, Drug Delivery, Formulation, Instrumentation, Method, Pharmaceuticals, Process, Therapeutics

Category(s): Chemicals, Drug Delivery, Pharmaceuticals, Instrumentation, Materials

High Throughput HDAC Inhibitor Assay

Summary: This invention provides a high-throughput, cost-effective, isoform-selective, human-based HDAC activity assay useful for understanding the activity of the 11 different HDAC isoforms present in humans. HDAC (Histone deacetylase) proteins are key regulators in gene expression and HDAC inhibitors represent an important new drug discovery target...

Published: 2/6/2014 | Inventor(s): Mary Pflum

Keywords(s): Assay

Category(s): Drug Discovery, Life Science, Assays

An In Vitro Model System for Studying Development of Human Preneoplastic Breast Disease

Wayne State University researchers have developed a novel model/assay system that recapitulates in vitro the in vivo processes that lead to breast cancer development and progression from preneoplastic tissue. This model is the first that demonstrates in vitro the de novo development and neoplastic conversion of functional alveolar units. Advantages...

Published: 3/31/2014 | Inventor(s): Malathy Shekhar, Larry Tait

Keywords(s): Assay, Breast Cancer

Category(s): Drug Discovery, Assays, Life Science, Oncology, Research tools

Biologically active ATP-Analogs for tagging phosphoproteins

A novel Photo Cross Linking Assay (PCLA) for targeting protein phosphorylation Protein phosphorylation catalyzed by kinases and phosphatases act at critical control points that regulates many cellular processes. This central role makes them an attractive target for identifying largely untapped and important biomarkers for disease diagnostics. Understanding...

Published: 3/31/2014 | Inventor(s): Mary Pflum

Keywords(s): Assay, Biomarker, Protein

Category(s): Chemicals, Life Science, Research tools, Assays, Reagents