Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

Case ID:

A Wayne State University researcher has derived new tumorigenic cell lines from the human prostate carcinoma cell line PC-3.  These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing the marrow cells in the bone cavity, invading adjacent bone and muscle tissue to ultimately form a palpable tumor at the hip joint. 
Patent Information:
For Information, Contact:
Joan Dunbar
Associate Vice President for Technology Commercialization
Wayne State University
(313) 577-5542
Gilda Hillman
Animal Model
Prostate Cancer
Research Tool