Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

Case ID:
98-449

A Wayne State University researcher has derived new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing the marrow cells in the bone cavity, invading adjacent bone and muscle tissue to ultimately form a palpable tumor at the hip joint.