Search Results - prostate+cancer

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Tumor Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT)

WSU and Duquesne University scientist have isolated a unique series of pyrrolopyrimidine antifolate analogs that show selective cytotoxicity toward solid tumors such as ovarian, prostate or breast cancer cells that express the low pH “proton-coupled folate transporter” (PCFT). The acidic pH optimum (pH 5.5-6.5) of PCFT makes it an ideal target...

Published: 3/31/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Analog or Analogue, Breast Cancer, Cancer Therapies, Drug Delivery, Ovarian Cancer, Prostate Cancer

Category(s): Therapeutics, Life Science, Small molecule, Oncology

Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice

A Wayne State University researcher has developed new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Oncology, Research tools

Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

A Wayne State University researcher has derived new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Research tools, Oncology