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Novel Dual and Triple Acting CNS Compounds with Potential as Antidepressants, Medications for Attention Deficit Disorders and other Related Neuro-disorders

Wayne State University researchers have identified compounds with a unique molecular template exhibiting reuptake inhibition activity for both at the norepinephrine and serotonin transporters in the CNS. In addition, some of these molecules also exhibit triple reuptake activity for the dopamine, serotonin and norepinephrine transporters. These...

Published: 2/6/2014 | Inventor(s): Aloke Dutta

Keywords(s): Antidepressants, Attention Deficit Disorders, Neuro-disorders, Neuroscience

Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders

CNS Compounds Specific for the Monoamine Transporter Systems

The dopamine transporter (DAT) plays an important role in pathophysiological processes in the central nervous system. In cocaine addiction, binding of cocaine to the DAT and consequent blockage of dopamine uptake appears to be related to the reinforcing properties of the drug. Also associated with the transport function is concentration of neurotoxic...

Published: 3/31/2014 | Inventor(s): Aloke Dutta

Keywords(s): Addiction Treatment, Antidepressants, Neuroscience, Parkinson's

Category(s): Therapeutics, Life Science