Search Results - larry+matherly

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Folate Receptor Targeted Therapeutics for Cancer

Collaborative researchers at WSU and Duquesne University have developed a series of novel folate analogs that show selective toxicity toward tumor cells expressing high levels of the surface protein folate receptor. Typically, normal cells express low levels of folate receptors or such receptors exhibit apical localization and are not exposed to...

Published: 2/6/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Biotechnology, Cancer, Cancer Therapies

Category(s): Therapeutics, Life Science, Oncology

Tumor Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT)

WSU and Duquesne University scientist have isolated a unique series of pyrrolopyrimidine antifolate analogs that show selective cytotoxicity toward solid tumors such as ovarian, prostate or breast cancer cells that express the low pH “proton-coupled folate transporter” (PCFT). The acidic pH optimum (pH 5.5-6.5) of PCFT makes it an ideal target...

Published: 3/31/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Analog or Analogue, Breast Cancer, Cancer Therapies, Drug Delivery, Ovarian Cancer, Prostate Cancer

Category(s): Therapeutics, Life Science, Small molecule, Oncology