Search Results - breast+cancer

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Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...

Published: 2/6/2014 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

Tumor Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT)

WSU and Duquesne University scientist have isolated a unique series of pyrrolopyrimidine antifolate analogs that show selective cytotoxicity toward solid tumors such as ovarian, prostate or breast cancer cells that express the low pH “proton-coupled folate transporter” (PCFT). The acidic pH optimum (pH 5.5-6.5) of PCFT makes it an ideal target...

Published: 3/31/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Analog or Analogue, Breast Cancer, Cancer Therapies, Drug Delivery, Ovarian Cancer, Prostate Cancer

Category(s): Therapeutics, Life Science, Small molecule, Oncology

Method For Treating and/or Imaging Breast Cancer Using Radioactive Iodine

This invention involves treating a breast cancer patient by the administration of a radioisotope of iodine in a dosage of between 5 and 50 milliCuries over the course of a day. The therapeutic composition is designed for mammary tissue uptake and includes an inorganic radioactive iodide salt (e.g., alkali metal, alkali earth or transition metal...

Published: 3/31/2014 | Inventor(s): James Rillema

Keywords(s): Anti-cancer, Breast Cancer, Cancer Therapies, Imaging, Therapeutics

Category(s): Therapeutics, Life Science, Oncology, Receptors/targets, Diagnostic, Imaging

An In Vitro Model System for Studying Development of Human Preneoplastic Breast Disease

Wayne State University researchers have developed a novel model/assay system that recapitulates in vitro the in vivo processes that lead to breast cancer development and progression from preneoplastic tissue. This model is the first that demonstrates in vitro the de novo development and neoplastic conversion of functional alveolar units. Advantages...

Published: 3/31/2014 | Inventor(s): Malathy Shekhar, Larry Tait

Keywords(s): Assay, Breast Cancer

Category(s): Drug Discovery, Assays, Life Science, Oncology, Research tools