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Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 2/6/2014 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

Folate Receptor Targeted Therapeutics for Cancer

Collaborative researchers at WSU and Duquesne University have developed a series of novel folate analogs that show selective toxicity toward tumor cells expressing high levels of the surface protein folate receptor. Typically, normal cells express low levels of folate receptors or such receptors exhibit apical localization and are not exposed to...

Published: 2/6/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Biotechnology, Cancer, Cancer Therapies

Category(s): Therapeutics, Life Science, Oncology

Galectin-3 Single Nucleotide Polymorphism rs4644 Predicts Human Cancer Risk Associated with Racial Disparity

This invention is a new diagnostic tool which allows prediction of cancer risk based on a single nucleotide polymorphism of a gene whose protein is over-expressed in various cancers. The polymorphism results in a single amino acid change. DNA analysis demonstrated that 98% of cancer patients tested had the mutation while normal donors did not....

Published: 3/31/2014 | Inventor(s): Avraham Raz, Pratima NangiA-Maker, Vitaly Balan

Keywords(s): Biotechnology, Cancer, Cancer risk, Diagnostics

Category(s): Diagnostic, Life Science, Oncology

GlyB4 Fusion with Neuregulin Heparin-Targeting Domain to Block Neuregulin Signaling

We have harnessed this natural targeting ability of NRG by fusing the HBD of NRG to soluble HER4. This fusion protein retains high affinity heparin binding to heparin and to cells that express heparan sulfates resulting in a more potent NRG antagonist. In vivo, it is targeted to peripheral nerve segments where it blocks the activity of NRG as a Schwann...

Published: 2/6/2014 | Inventor(s): Jeffrey Loeb, Qunfang Lee

Keywords(s): Anti-cancer, Biotechnology, Cancer risk, Cancer Therapies, Drug Delivery, Drug Target, Epilepsy

Category(s): Life Science, Drug Delivery, Other

Novel Method of Making 3-Dimensional Neural Probes

WSU researchers have developed a unique design for neural probes with both electrical and chemical interfaces, via arrays metal electrodes and micro-channels that can be easily manufactured and folded in 3D arrays. The fabrication process is post-CMOS compatible allowing simple, reliable and cost effective construction of the all the components. Methods...

Published: 2/6/2014 | Inventor(s): Yong Xu, Yuefa Li

Keywords(s): Biotechnology, Drug Delivery, Epilepsy, Microchannels, Neural Probes, Neuroscience

Category(s): Drug Delivery, Life Science, Medical Devices, Other, MEMS, Microfluidics, Physical Sciences, Sensors

Microfluidic Particle Concentration and Separator

Researchers at the Wayne State University Smart Sensors and Integrated Microsystems (SSIM) laboratory have developed a micro-scale concentrator and separator applicable to several microfluidic applications. Initially the device was developed to concentrate and separate bacteria from other impurities to test water quality however the micro separator...

Published: 2/6/2014 | Inventor(s): Gregory Auner, ChunG-Chu Chen

Keywords(s): Biotechnology

Category(s): Physical Sciences, Microfluidics, MEMS