Search Results - Metabolic+disorders

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Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...

Published: 3/31/2014 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

DNA Molecule Encoding the B3 Adrenegic Receptor

The B3-Adrenergic receptor protein and DNA which encodes same, vectors containing the DNA, host cells transformed with the vectors and methods of using the protein, the DNA and the transformed host cells. Widely licensed on a non-exclusive basis for diabetes research. U.S. Patent #5,364,772.

Published: 3/31/2014 | Inventor(s): James Granneman, Kristine Lahners, Donald Rao

Keywords(s): Disease, DNA, Drug Target, Therapeutics

Category(s): Drug Screening, Diseases, Life Science, Small molecule, Therapeutics, Metabolic disorders

Novel Mammalian Putative Phosphatidylinositol-4-Phosphate-5-Kinase

Researchers at Wayne State University have discovered a novel mammalian gene which may be involved in membrane trafficking, more specifically, insulin-induced translocation of the fat/muscle-specific glucose transporter GLUT4. This material is a potentially valuable research tool for investigation relating to the diagnosis or therapy of diabetes....

Published: 3/31/2014 | Inventor(s): Assia Shisheva

Keywords(s): DNA, Drug Target, Therapeutics

Category(s): Biotechnology, Diseases, Life Science, Metabolic disorders, Therapeutics