Search Results - nano-based

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Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...

Published: 3/31/2014 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

Nanoparticle Method to Stabilize Suspension-Based pMDI HFA Formulations

Novel nanoparticle-based drug compositions and methods that improve and expand therapeutic drug delivery to the lungs through pressurized meter-dose inhalers (pMDIs). A large variety of approaches have been developed at WSU aimed at improving the aerosol characteristics and expanding the range of target species deliverable. These improved formulations...

Published: 2/6/2014 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals

Category(s): Drug Delivery, Life Science, Nano-based, Therapeutics

Improved pDMI Inhaler Formulations

Novel biodegradable, non-toxic nanoparticles that act as stabilizing excipients with a wide variety of suspension drug candidates including polar & non-polar drug particles, bio-macromolecules (proteins/peptides), gene therapies (DNA/siRNA) as well as amorphous and crystalline therapeutics have been developed which provide a platform for improving...

Published: 2/6/2014 | Inventor(s): Sandro Da Rocha, Libo Wu

Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Life Science, Therapeutics, Nano-based

Drug-Dendrimer Nanoparticles for Targeted Treatment of Neuroinflammation

Highly effective dendrimer-drug based compositions and methods for treatment have been developed that target neuroinflammation both in the brain and the retina upon intravenous administration. The nanodevices overcome the blood-brain barrier (BBB) and deliver drugs to target cells (activated microglia and astrocytes) producing dramatic therapeutic improvements....

Published: 3/31/2014 | Inventor(s): Rangaramanujam Kannan, Raymond Iezzi, Bharath Rajaguru, Sujatha Kannan

Keywords(s): Alzheimer's Disease, Compound, Disease, Drug Delivery, Imaging, Nanomaterials, Nanotechnology, Neural Probes, Neuro-disorders, Parkinson's, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Therapeutics, Diseases, Life Science, Nano-based, Vision, Imaging, Neurological disorders, Dendrimer