Search Results - imaging

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Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...

Published: 2/6/2014 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 2/6/2014 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

Magnetic Resonance Force Microscopy for Molecular Imaging

Detailed Description Magnetic Resonance Force Microscopy (MRFM) is an emerging technology that combines the strengths of magnetic resonance and force microscopy to achieve high resolution three-dimensional sub-surface imaging of a test substance. WSU researchers have adapted and refined MRFM to study biological systems such as isolated cells sub-cellular...

Published: 3/31/2014 | Inventor(s): Stanley Fricke, Gregory Moore

Keywords(s): Imaging

Category(s): Devices, Imaging, Life Science, MRI

Method For Treating and/or Imaging Breast Cancer Using Radioactive Iodine

This invention involves treating a breast cancer patient by the administration of a radioisotope of iodine in a dosage of between 5 and 50 milliCuries over the course of a day. The therapeutic composition is designed for mammary tissue uptake and includes an inorganic radioactive iodide salt (e.g., alkali metal, alkali earth or transition metal...

Published: 3/31/2014 | Inventor(s): James Rillema

Keywords(s): Anti-cancer, Breast Cancer, Cancer Therapies, Imaging, Therapeutics

Category(s): Therapeutics, Life Science, Oncology, Receptors/targets, Diagnostic, Imaging

Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...

Published: 3/31/2014 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

Drug-Dendrimer Nanoparticles for Targeted Treatment of Neuroinflammation

Highly effective dendrimer-drug based compositions and methods for treatment have been developed that target neuroinflammation both in the brain and the retina upon intravenous administration. The nanodevices overcome the blood-brain barrier (BBB) and deliver drugs to target cells (activated microglia and astrocytes) producing dramatic therapeutic improvements....

Published: 3/31/2014 | Inventor(s): Rangaramanujam Kannan, Raymond Iezzi, Bharath Rajaguru, Sujatha Kannan

Keywords(s): Alzheimer's Disease, Compound, Disease, Drug Delivery, Imaging, Nanomaterials, Nanotechnology, Neural Probes, Neuro-disorders, Parkinson's, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Therapeutics, Diseases, Life Science, Nano-based, Vision, Imaging, Neurological disorders, Dendrimer

Next Generation MRI Contrast Imaging Agent

WSU has developed a new class of contrast agents that are effective at ultra-high field strengths (>3 tesla) in magnetic resonance imaging (MRI) where current clinical agents severely decline in effectiveness. Our new agents are based on the metal Eu(II) which is novel compared to current agents that are based on Gd(III). The difference between the...

Published: 2/6/2014 | Inventor(s): Matthew Allen, Nipuni Gamage, Yujiang Mei, Joel Garcia, Jeremiah Moore

Keywords(s): Compound, Diagnostic, Imaging, MRI, Positive Imaging Agent

Category(s): Imaging, Chemicals, Life Science, MRI, Physical Sciences, Specialty compounds