Search Results - biologicals

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Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...

Published: 2/6/2014 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases

Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...

Published: 3/31/2014 | Inventor(s): David Oupicky, Jing Li

Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals

Peptides Representing Genus-Specific Chlamydial Antigens for Vaccine Peptide Vaccines for Chlamydia to be Delivered Orally or by Other Mucosal Routes

Background Despite increased surveillance and treatment, sexually transmitted disease infections caused by Chlamydia continue to rise. It is estimated that over 20 million new cases of infection occur annually in developed countries, with over 75 million new cases occurring annually in developing countries. Chlamydial genital tract infection is...

Published: 3/31/2014 | Inventor(s): Judith WhittuM-Hudson, Alan Hudson

Keywords(s): Vaccines

Category(s): Pharmaceuticals, Biologicals, Life Science, Therapeutics, Vaccines

Gene for Chicken Interleukin 15...

Detailed Description WSU researchers have cloned and patented chicken IL-2 and related avian lymphokines for use as avian vaccine adjuvants. The inventors have shown experimentally that chicken IL-2 can enhance vaccine effectiveness in chickens. Future research to further enable this technology will likely include optimization of delivery methods....

Published: 3/31/2014 | Inventor(s): Roy Sundick, Lily Jones, David Smith

Keywords(s): DNA, Vaccines

Category(s): Animal/Veterinary, Biologicals, Life Science, Therapeutics, Vaccines