Search Results - disease

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Modified Ectodomain of Human EGFR as a Potential Anticancer Agent

Development of a protein that attenuates EGFR and/or EGFR family members and is comprised of a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion of the EGFR (or EGFR family member) and the "U" region epitope of EGFR related protein (ERRP), wherein the portion of the EGFR...

Published: 2/6/2014 | Inventor(s): Adhip Majumdar, Arun Rishi, Yingjie Yu

Keywords(s): Breast Cancer, Cancer, Cancer Therapies, Disease, Drug Target, Protein, Therapeutics

Category(s): Life Science, Biologicals, Diseases, Oncology

Loop-Mediated Isothermal Amplification (LAMP) Assay for Meningitis

Summary: A novel LAMP assay has been developed for detection of Neisseria meningitidis (Nm) in patient samples. Six sets of unique primers have been designed which dramatically improve sensitivity of Nm detection and enable discrimination of the six major Nm serogroups (A, B, C, W-135, X, and Y) with limits as low as 1 (one) genomic copy per reaction....

Published: 2/6/2014 | Inventor(s): Mitsuko Seki, Dong Wook Kim, Paul Kilgore

Keywords(s): Diagnostic, Disease, Vaccines

Category(s): Diagnostic, Life Science, Infectious disease, Research tools, Assays

Drug-Dendrimer Nanoparticles for Targeted Treatment of Neuroinflammation

Highly effective dendrimer-drug based compositions and methods for treatment have been developed that target neuroinflammation both in the brain and the retina upon intravenous administration. The nanodevices overcome the blood-brain barrier (BBB) and deliver drugs to target cells (activated microglia and astrocytes) producing dramatic therapeutic improvements....

Published: 3/31/2014 | Inventor(s): Rangaramanujam Kannan, Raymond Iezzi, Bharath Rajaguru, Sujatha Kannan

Keywords(s): Alzheimer's Disease, Compound, Disease, Drug Delivery, Imaging, Nanomaterials, Nanotechnology, Neural Probes, Neuro-disorders, Parkinson's, Pharmaceuticals, Therapeutics

Category(s): Drug Delivery, Therapeutics, Diseases, Life Science, Nano-based, Vision, Imaging, Neurological disorders, Dendrimer

DNA Molecule Encoding the B3 Adrenegic Receptor

The B3-Adrenergic receptor protein and DNA which encodes same, vectors containing the DNA, host cells transformed with the vectors and methods of using the protein, the DNA and the transformed host cells. Widely licensed on a non-exclusive basis for diabetes research. U.S. Patent #5,364,772.

Published: 3/31/2014 | Inventor(s): James Granneman, Kristine Lahners, Donald Rao

Keywords(s): Disease, DNA, Drug Target, Therapeutics

Category(s): Drug Screening, Diseases, Life Science, Small molecule, Therapeutics, Metabolic disorders