Search Results - rafael+fridman

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Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but not...

Published: 2/6/2014 | Inventor(s): Shahriar Mobashery, Rafael Fridman

Keywords(s):

Category(s): Therapeutics, Life Science, Small molecule, Diseases

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

This invention is a method for the identification of MMP enzyme activity in tissue. MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed, in part, because there is no reliable biomarker to determine MMP activity in tissue. This invention...

Published: 3/31/2014 | Inventor(s): Avraham Raz, Rafael Fridman, Pratima NangiA-Maker

Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method

Category(s): Diagnostic, Life Science, Oncology