Search Results - diagnostics

4 Results

Sort By:

Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...

Published: 2/6/2014 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines

Galectin-3 Single Nucleotide Polymorphism rs4644 Predicts Human Cancer Risk Associated with Racial Disparity

This invention is a new diagnostic tool which allows prediction of cancer risk based on a single nucleotide polymorphism of a gene whose protein is over-expressed in various cancers. The polymorphism results in a single amino acid change. DNA analysis demonstrated that 98% of cancer patients tested had the mutation while normal donors did not....

Published: 3/31/2014 | Inventor(s): Avraham Raz, Pratima NangiA-Maker, Vitaly Balan

Keywords(s): Biotechnology, Cancer, Cancer risk, Diagnostics

Category(s): Diagnostic, Life Science, Oncology

Imaging Tandem Mass Spectrometry: Reduction to Practice

Currently, tandem mass spectrometry is typically performed by selecting a single mass peak in a time of flight or quadrupole mass spectrometer, which is then fragmented through collision, after which the products are mass-selected in a quadrupole or similar secondary mass spectrometer. A Wayne State University researcher has developed an alternative...

Published: 2/6/2014 | Inventor(s): Arthur Suits, Myung Kim, Brian Leskiw

Keywords(s): Diagnostics, Instrumentation, Method

Category(s): Instrumentation, Physical Sciences, Spectroscopy, Imaging, Other

A Diagnostic Marker for Matrix Metalloprotease (MMP)-2 and -9 Activity in Cancer Tissue

This invention is a method for the identification of MMP enzyme activity in tissue. MMPs are involved in tumor progression and therefore are targets for anti-cancer drug therapies. However, most drug therapies directed at inhibition of MMPs have failed, in part, because there is no reliable biomarker to determine MMP activity in tissue. This invention...

Published: 3/31/2014 | Inventor(s): Avraham Raz, Rafael Fridman, Pratima NangiA-Maker

Keywords(s): Biomarker, Cancer, Diagnostics, Enzyme, Method

Category(s): Diagnostic, Life Science, Oncology