Search Results - cell+lines

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Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...

Published: 2/6/2014 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines

Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice

A Wayne State University researcher has developed new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Oncology, Research tools

Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

A Wayne State University researcher has derived new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Research tools, Oncology

Establishment of a New Renal Cell Carcinoma Cell Line and a New Experimental Renal Tumor Model

A tumor cell line from a primary papillary renal cell carcinoma (RCC) (nuclear grade III/IV). This cell line, known as KCI-18, when implanted in the kidney of nude mice provides a xenograft tumor model of RCC. The KCI-18 cell line is highly tumorigenic, with lung metastases forming from the primary tumor as in human renal cell carcinoma. File...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Oncology, Research tools