Search Results - Small+molecule

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Tumor Targeting by Small Molecule Therapeutics for a Proton-Coupled Folate Transporter (PCFT)

WSU and Duquesne University scientist have isolated a unique series of pyrrolopyrimidine antifolate analogs that show selective cytotoxicity toward solid tumors such as ovarian, prostate or breast cancer cells that express the low pH “proton-coupled folate transporter” (PCFT). The acidic pH optimum (pH 5.5-6.5) of PCFT makes it an ideal target...

Published: 3/31/2014 | Inventor(s): Larry Matherly, Aleem Gangjee

Keywords(s): Analog or Analogue, Breast Cancer, Cancer Therapies, Drug Delivery, Ovarian Cancer, Prostate Cancer

Category(s): Therapeutics, Life Science, Small molecule, Oncology

Designer Aminoglycosides

Wayne State University researchers have synthesized a series of novel aminoglycoside antibiotics that have shown enhanced antibacterial activity, low susceptibility to existing resistance mechanisms and low toxicity when compared to currently marketed aminoglycosides. Aminoglycoside antibiotics have been used against a wide variety of bacterial...

Published: 2/6/2014 | Inventor(s): Shahriar Mobashery, Lakshmi Kotra, Jalal Haddad

Keywords(s): Antibiotics

Category(s): Therapeutics, Life Science, Small molecule, Diseases, Infectious disease

Novel Prenyl Transferase Inhibitors

A series of farnesol and geranylgeraniol analogs that block the prenylation of proteins in cells. The diphosphate derivatives of these compounds are potent inhibitors of protein prenyltransferases in vitro. One allylfarnesol compound specifically inhibits the farnesylation of proteins and one allylgeranylgeraniol compound specifically inhibits the...

Published: 2/6/2014 | Inventor(s): Richard Gibbs

Keywords(s):

Category(s): Therapeutics, Life Science, Small molecule

Novel Dual and Triple Acting CNS Compounds with Potential as Antidepressants, Medications for Attention Deficit Disorders and other Related Neuro-disorders

Wayne State University researchers have identified compounds with a unique molecular template exhibiting reuptake inhibition activity for both at the norepinephrine and serotonin transporters in the CNS. In addition, some of these molecules also exhibit triple reuptake activity for the dopamine, serotonin and norepinephrine transporters. These...

Published: 2/6/2014 | Inventor(s): Aloke Dutta

Keywords(s): Antidepressants, Attention Deficit Disorders, Neuro-disorders, Neuroscience

Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders

Novel Hybrid Series of Compound Derived from 2-Aminotetralin and Piperazine Based Derivatives: Characterization for D1, D2, D3, D4 and other Serotonin Receptor Subtypes Binding

A series of compounds derived from 2-aminotetralin and piperazine fragments have been synthesized, which exhibit high CNS activity in vivo and in vitro. Some of the selected lead compounds have exhibited potent in vivo activity in a Parkinson’s disease animal model with long extended duration of action. In particular, these compounds show high...

Published: 2/6/2014 | Inventor(s): Aloke Dutta, XianG-Shu Fei

Keywords(s):

Category(s): Therapeutics, Diseases, Life Science, Small molecule, Neurological disorders

DNA Molecule Encoding the B3 Adrenegic Receptor

The B3-Adrenergic receptor protein and DNA which encodes same, vectors containing the DNA, host cells transformed with the vectors and methods of using the protein, the DNA and the transformed host cells. Widely licensed on a non-exclusive basis for diabetes research. U.S. Patent #5,364,772.

Published: 3/31/2014 | Inventor(s): James Granneman, Kristine Lahners, Donald Rao

Keywords(s): Disease, DNA, Drug Target, Therapeutics

Category(s): Drug Screening, Diseases, Life Science, Small molecule, Therapeutics, Metabolic disorders

Inhibitors of Matrix Metalloproteinases

Wayne State University researchers and academic collaborators have prepared the first reported mechanism-based inhibitors for matrix metalloproteinases (MMPs). One of the novel compounds (SB-3CT) shows selectivity for the gelatinases (two members of the MMP family), which have been implicated in various pathological conditions including, but not...

Published: 2/6/2014 | Inventor(s): Shahriar Mobashery, Rafael Fridman

Keywords(s):

Category(s): Therapeutics, Life Science, Small molecule, Diseases

Enzyme activated nitric oxide donors

This invention relates to a series of new pro-drug nitric oxide donor compositions. Nitric oxide (NO) is a crucial signaling and regulating molecule with wide-ranging functions in the cardiovascular, nervous and immune systems, such as blood vessel relaxation, neurotransmission and pathogen suppression. Delivery of supplementary NO through NO donor...

Published: 2/6/2014 | Inventor(s): Peng George Wang, Xuejun Wu, Xiaoping Tang

Keywords(s):

Category(s): Chemicals, Life Science, Therapeutics, Small molecule