Search Results - %22Life+Science%22+and+%22Research+Tools%22+and+%22Assays%22

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Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors
This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...
Published: 2/6/2014   |   Inventor(s): Leon Carlock, Maria Cypher
Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics
Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines
Loop-Mediated Isothermal Amplification (LAMP) Assay for Meningitis
Summary: A novel LAMP assay has been developed for detection of Neisseria meningitidis (Nm) in patient samples. Six sets of unique primers have been designed which dramatically improve sensitivity of Nm detection and enable discrimination of the six major Nm serogroups (A, B, C, W-135, X, and Y) with limits as low as 1 (one) genomic copy per reaction....
Published: 2/6/2014   |   Inventor(s): Mitsuko Seki, Dong Wook Kim, Paul Kilgore
Keywords(s): Diagnostic, Disease, Vaccines
Category(s): Diagnostic, Life Science, Infectious disease, Research tools, Assays
Peptide Antimicrobial
In vivo Display Technology for the Isolation of Antimicrobial Peptides Professor Philip R. Cunningham, Ph.D. Department of Biological Sciences @ Wayne State University Interest in peptides as antimicrobial agents has increased dramatically in recent years, driven primarily by the development of new technologies for producing, screening and analyzing...
Published: 2/6/2014   |   Inventor(s): Philip Cunningham, Wes Colangelo
Keywords(s):  
Category(s): Pharmaceuticals, Life Science, Research tools, Assays, Biological materials, Protein/peptides
An In Vitro Model System for Studying Development of Human Preneoplastic Breast Disease
Wayne State University researchers have developed a novel model/assay system that recapitulates in vitro the in vivo processes that lead to breast cancer development and progression from preneoplastic tissue. This model is the first that demonstrates in vitro the de novo development and neoplastic conversion of functional alveolar units. Advantages...
Published: 3/31/2014   |   Inventor(s): Malathy Shekhar, Larry Tait
Keywords(s): Assay, Breast Cancer
Category(s): Drug Discovery, Assays, Life Science, Oncology, Research tools
Fluorescence-Based Assay for Demethylation
Detailed Description WSU researchers have developed a fluorescence-based assay for the dealkylation activity of the non-heme iron (II) a-ketoglutarate-dependent dioxygenase family of enzymes. This assay uses formaldehyde dehydrogenase to convert formaldehyde to formic acid and monitors the creation of an NADH analog using fluorescence. The technology...
Published: 2/6/2014   |   Inventor(s): Ashok Bhagwat, Todd Roy
Keywords(s):  
Category(s): Assays, Life Science, Research tools
Biologically active ATP-Analogs for tagging phosphoproteins
A novel Photo Cross Linking Assay (PCLA) for targeting protein phosphorylation Protein phosphorylation catalyzed by kinases and phosphatases act at critical control points that regulates many cellular processes. This central role makes them an attractive target for identifying largely untapped and important biomarkers for disease diagnostics. Understanding...
Published: 3/31/2014   |   Inventor(s): Mary Pflum
Keywords(s): Assay, Biomarker, Protein
Category(s): Chemicals, Life Science, Research tools, Assays, Reagents