Search Results - Assays

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Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...

Published: 2/6/2014 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines

Loop-Mediated Isothermal Amplification (LAMP) Assay for Meningitis

Summary: A novel LAMP assay has been developed for detection of Neisseria meningitidis (Nm) in patient samples. Six sets of unique primers have been designed which dramatically improve sensitivity of Nm detection and enable discrimination of the six major Nm serogroups (A, B, C, W-135, X, and Y) with limits as low as 1 (one) genomic copy per reaction....

Published: 2/6/2014 | Inventor(s): Mitsuko Seki, Dong Wook Kim, Paul Kilgore

Keywords(s): Diagnostic, Disease, Vaccines

Category(s): Diagnostic, Life Science, Infectious disease, Research tools, Assays

Peptide Antimicrobial

In vivo Display Technology for the Isolation of Antimicrobial Peptides Professor Philip R. Cunningham, Ph.D. Department of Biological Sciences @ Wayne State University Interest in peptides as antimicrobial agents has increased dramatically in recent years, driven primarily by the development of new technologies for producing, screening and analyzing...

Published: 2/6/2014 | Inventor(s): Philip Cunningham, Wes Colangelo

Keywords(s):

Category(s): Pharmaceuticals, Life Science, Research tools, Assays, Biological materials, Protein/peptides

High Throughput HDAC Inhibitor Assay

Summary: This invention provides a high-throughput, cost-effective, isoform-selective, human-based HDAC activity assay useful for understanding the activity of the 11 different HDAC isoforms present in humans. HDAC (Histone deacetylase) proteins are key regulators in gene expression and HDAC inhibitors represent an important new drug discovery target...

Published: 2/6/2014 | Inventor(s): Mary Pflum

Keywords(s): Assay

Category(s): Drug Discovery, Life Science, Assays

An In Vitro Model System for Studying Development of Human Preneoplastic Breast Disease

Wayne State University researchers have developed a novel model/assay system that recapitulates in vitro the in vivo processes that lead to breast cancer development and progression from preneoplastic tissue. This model is the first that demonstrates in vitro the de novo development and neoplastic conversion of functional alveolar units. Advantages...

Published: 3/31/2014 | Inventor(s): Malathy Shekhar, Larry Tait

Keywords(s): Assay, Breast Cancer

Category(s): Drug Discovery, Assays, Life Science, Oncology, Research tools

Fluorescence-Based Assay for Demethylation

Detailed Description WSU researchers have developed a fluorescence-based assay for the dealkylation activity of the non-heme iron (II) a-ketoglutarate-dependent dioxygenase family of enzymes. This assay uses formaldehyde dehydrogenase to convert formaldehyde to formic acid and monitors the creation of an NADH analog using fluorescence. The technology...

Published: 2/6/2014 | Inventor(s): Ashok Bhagwat, Todd Roy

Keywords(s):

Category(s): Assays, Life Science, Research tools

Biologically active ATP-Analogs for tagging phosphoproteins

A novel Photo Cross Linking Assay (PCLA) for targeting protein phosphorylation Protein phosphorylation catalyzed by kinases and phosphatases act at critical control points that regulates many cellular processes. This central role makes them an attractive target for identifying largely untapped and important biomarkers for disease diagnostics. Understanding...

Published: 3/31/2014 | Inventor(s): Mary Pflum

Keywords(s): Assay, Biomarker, Protein

Category(s): Chemicals, Life Science, Research tools, Assays, Reagents