Search Results - %22Life+Science%22+and+%22Research+Tools%22

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Translation Regulated (TR)-Mediated Gene Expression: Novel Expression and Reporter Vectors

This is a cell based vector system that is able to monitor the transition, in cell lines, from Cap dependent to Cap independent translation. This shift is critical in determining if a cell, that is placed under significant stress (such as treatment with a chemotherapeutic agent), recovers or undergoes programmed cell death (apoptosis). This information...

Published: 2/6/2014 | Inventor(s): Leon Carlock, Maria Cypher

Keywords(s): Animal Model, Anti-cancer, Cancer, Cancer risk, Cancer Therapies, Diagnostics, Imaging, Therapeutics

Category(s): Life Science, Diagnostics, Research tools, Assays, Cell lines

Loop-Mediated Isothermal Amplification (LAMP) Assay for Meningitis

Summary: A novel LAMP assay has been developed for detection of Neisseria meningitidis (Nm) in patient samples. Six sets of unique primers have been designed which dramatically improve sensitivity of Nm detection and enable discrimination of the six major Nm serogroups (A, B, C, W-135, X, and Y) with limits as low as 1 (one) genomic copy per reaction....

Published: 2/6/2014 | Inventor(s): Mitsuko Seki, Dong Wook Kim, Paul Kilgore

Keywords(s): Diagnostic, Disease, Vaccines

Category(s): Diagnostic, Life Science, Infectious disease, Research tools, Assays

Hyperaccumulation of Arsenic in S. Cerevisiae

Detailed Description WSU faculty developed an innovative biological technology that has promise to cost-effectively remove arsenic from drinking water. The technology employs the use of a genetically engineered strain of yeast with the ability to hyper-accumulate arsenic without releasing the arsenic back into the environment. The yeast is being...

Published: 3/31/2014 | Inventor(s): Barry Rosen, Mallika Ghosh

Keywords(s): Reagents

Category(s): Environment, Life Science, Reagents, Research tools

Laser Spray Ionization (LSI) Method for Mass Spectrometry Imaging

Technology Summary: Laser Spray Ionization (LSI) is a novel inlet ionization method for mass spectrometry invented at WSU which can be used to create predominately multiply charged ions from solid samples at atmospheric pressure. Unlike MALDI ionization methods which are typically limited to producing singly charged species for larger molecules, LSI...

Published: 2/6/2014 | Inventor(s): Sarah Trimpin, Thushani Nikeshala, Ellen Inutan, John Maarouf

Keywords(s): Biotechnology, Imaging

Category(s): Instrumentation, Imaging, Characterization, Other, Physical Sciences, Spectroscopy, Life Science, Research tools

Peptide Antimicrobial

In vivo Display Technology for the Isolation of Antimicrobial Peptides Professor Philip R. Cunningham, Ph.D. Department of Biological Sciences @ Wayne State University Interest in peptides as antimicrobial agents has increased dramatically in recent years, driven primarily by the development of new technologies for producing, screening and analyzing...

Published: 2/6/2014 | Inventor(s): Philip Cunningham, Wes Colangelo

Keywords(s):

Category(s): Pharmaceuticals, Life Science, Research tools, Assays, Biological materials, Protein/peptides

Establishment of a Metastatic Prostate Carcinoma Tumor Model in Mice

A Wayne State University researcher has developed new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/PI, are highly tumorigenic when implanted in the prostate of nude mice, providing a xenograft tumor model of prostate carcinoma. In this model, lymph node metastases form from the primary...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Cancer, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Oncology, Research tools

Nano-beaker array formation process and its use for high-throughput loading and crystallization screening and other lab-on-the-chip applications

Wayne State University researchers have invented a novel process to make array patterns and its use for high-throughput screening of crystallization conditions, liquid solution applications, and other lab-on-the-chip applications. The formation process is a variation of “particle lithography” in which microparticles such as polystyrene microparticles...

Published: 2/6/2014 | Inventor(s): Guangzhao Mao, Daniel Sobczynski, Sunxi Wang, Eugene Xhahysa, Pedram Jahanian

Keywords(s): Nanotechnology

Category(s): Physical Sciences, Microfluidics, MEMS, Research tools, Life Science, Other

Establishment of a Prostate Carcinoma Bone Tumor Model in Mice

A Wayne State University researcher has derived new tumorigenic cell lines from the human prostate carcinoma cell line PC-3. These cell lines, known as PC-3/IF, when implanted in the femurs of nude mice, provide a xenograft tumor model of bone metastatic prostate carcinoma. The PC-3/IF cell lines are highly tumorigenic, with tumor cells replacing...

Published: 3/31/2014 | Inventor(s): Gilda Hillman

Keywords(s): Animal Model, Prostate Cancer, Research Tool

Category(s): Drug Discovery, Animal models, Cell lines, Life Science, Research tools, Oncology

An In Vitro Model System for Studying Development of Human Preneoplastic Breast Disease

Wayne State University researchers have developed a novel model/assay system that recapitulates in vitro the in vivo processes that lead to breast cancer development and progression from preneoplastic tissue. This model is the first that demonstrates in vitro the de novo development and neoplastic conversion of functional alveolar units. Advantages...

Published: 3/31/2014 | Inventor(s): Malathy Shekhar, Larry Tait

Keywords(s): Assay, Breast Cancer

Category(s): Drug Discovery, Assays, Life Science, Oncology, Research tools

Fluorescence-Based Assay for Demethylation

Detailed Description WSU researchers have developed a fluorescence-based assay for the dealkylation activity of the non-heme iron (II) a-ketoglutarate-dependent dioxygenase family of enzymes. This assay uses formaldehyde dehydrogenase to convert formaldehyde to formic acid and monitors the creation of an NADH analog using fluorescence. The technology...

Published: 2/6/2014 | Inventor(s): Ashok Bhagwat, Todd Roy

Keywords(s):

Category(s): Assays, Life Science, Research tools

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